![]() ![]() MELD-Na is modified MELD which introduced serum sodium concentration 5. It was used as a liver transplant liver source allocation basis to determine the order of patients undergoing liver transplantation by the United Network for Organ Sharing (UNOS). The MELD scoring system was established to evaluate the short-term prognosis of patients with liver cirrhosis after TIPS. CTP was established as early indicator for bleeding oesophageal varices. In such cases, both early diagnosis of ACLF and early prediction of prognosis are critical for distinguishing patients who require transplantation from those individuals who will survive following only intensive medical care.Ĭurrently, the most commonly used models to assess the severity of liver disease include the Child–Turcotte–Pugh (CTP) scoring system and the model for end-stage liver disease (MELD) scoring system –. Thus, comprehensive medical intervention which included absolute bed rest, energy supplements, intravenous drop infusion of albumin or plasma, maintenance of electrolyte or acid-base equilibrium, the use of glutathione, adenosylmethionine or branched-chain amino acids to nourish the liver cells, prevention and treatment for complications, is still the mainstay of treatment for patients with ACLF. Although liver transplant is considered to be the most effective treatment for ACLF, few patients benefit from this approach because of the shortage of liver donors and the high cost of the procedure. **Comparison of the training cohort with the validation cohortĪcute-on-chronic liver failure (ACLF) is a life-threatening clinical syndrome with a complicated etiology, varied manifestations and a short-term mortality rate of 50–90%. $$Based on bilirubin, creatinine, INR, sodium and cause (seconds). & Based on bilirubin, creatinine, INR and cause (seconds). $ Based on hepatic encephalopathy, ascites, bilirubin, albumin, and prothrombin time (seconds). #Includes HBV combined with drugs, HBV combined with alcohol, HBV combined with HGV, HBV combined with HAV, and HBV combined with surgery/trauma. #Includes HGV, alcohol, HCV, autoimmune, surgery/trauma, and cholestatic. *Includes HBV combined with schistosome HCV alcohol combined with schistosome autoimmune and cholestatic. Non-normal distribution continuous values are expressed as the median and interquartile range. ![]() Abbreviations: Abbreviation: ACLF, acute-to-chronic liver failure INR, international normalized ratio CTP, Child–Turcotte–Pugh scoring system MELD, model for end-stage liver disease scoring system NOTE: Normal distribution continuous values are expressed as the mean±SD. Table S2: Demographic, clinical, biochemical and hepatic-hemodynamic features in the training and validation cohorts. **Comparison of pre-ACLF with early-stage ACLF. ![]() $$ Based on bilirubin, creatinine, INR, sodium and cause (seconds). #Includes HBV combined with drug, HBV combined with alcohol, HBV combined with HGV, HBV combined with HAV and HBV combined with surgery/trauma. *Includes HBV combined with schistosome, HCV, alcohol combined with schistosome, autoimmune and cholestatic. Non-normal distribution continuous values were expressed as the median and interquartile range. Abbreviations: Abbreviation: ACLF, acute-to-chronic liver failure INR, international normalized ratio CTP, Child–Turcotte–Pugh scoring system MELD, model for end-stage liver disease scoring system Normal distribution continuous values were expressed as the mean±SD. Table S1: Baseline characteristics of patients with ACLF and pre-ACLF. ![]()
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